- Aqueous Formulation
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M-K is a safe anesthesia combination of Medetomidine HCl and Ketamine HCl, that can be used to immobilize a broad range of species. These two pharmaceuticals when used in combination of: Medetomidine (5 mg/ml) and Ketamine HCl (150 mg/ml), provides smooth induction times and excellent recovery. M-K immobilization can be easily reversed after 20 minutes with a single injection of Atipamezole HCl.
This highly effective combined formulation has been used in thousands of immobilizations and controlled studies for many years. As stated by Dr. Harry Jalanka in his noted 1990 study entitled: The Use of Medetomidine, Medetomidine-Ketamine Combinations, and Atipamezole in Nondomestic Mammals: A Review, “Medetomidine, a potent alpha2-agonist, in combination with the dissociative anesthetic ketamine, has been used to immobilize a variety of nondomestic mammals. The recent development of potent and specific alpha2-adrenoceptor agonists and antagonists has enhanced their use in nondomestic animal immobilization and reversal.
“While Medetomidine alone induces sedation in a dose-dependent way, and complete immobilization has been achieved with high doses in non-domestic animals, we feel that ketamine should be added to the immobilization mixture to ensure complete immobilization and operator safety. Clinically, the resulting immobilization is characterized by a smooth onset with, good to excellent myorelaxation. No fatalities attributable to this immobilization mixture have been reported in 1,500+ immobilizations.“
The α2-adrenoceptor antagonist, Atipamezole, is highly effective in reversing the immobilization induced by Medetomidine-Ketamine combinations. In ruminants, carnivores, marsupials, primates, and rodents the Medetomidine-Ketamine-induced immobilization has shown to be rapidly and persistently reversed with the Atipamezole antagonist.